HOD's Profile : Department of Chemistry


Personal Profile

 Prof A.A.Adesomoju

Akinbo Akinwumi ADESOMOJU

 B.Sc.(Hons), M.Sc., B.Sc; PhD (Ibadan), FICCON.  

Professor and HOD 

Area of Specializations:Natural Product Chemistry

Office:Room F104, Department of Chemistry,University of Ibadan

Tel: + 2348037879872


Contact:

a.adesomoju@mail.ui.edu.ng

Current Research Interest

Isolation and structural determination of compounds of medicinal, biological or technical importance from natural sources.

Publications

  1. Adesomoju, A.A., Okogun, J.I; Ekong, D.E.U. and Adedipe, N.O. (1979).  Hormonal aspects of the fruit abscission problem in cowpea (Vigna unguiculata L Walp.), Biochemie and Physiologie der pflazen, 174, 51 -57.
  2. Adesomoju, A.A.; Okogun J.I; Ekong, D.E.U. and Gaskin, P. (1980).  GC -MS identification of abscisic acid and abscisic acid metabolites in seeds of Vigna unguiculata.  Phytochemistry, 19, 223 -225.
  3. Adesomoju, A.A.; Okogun, J.I.; and Ekong, D.E.U. (1980). Identification of gibberellins A4, A6, A8 and A17 in immature fruits of cowpea, (Vigna unguicalata L Walp.) Nigerian Journal of Natural Sciences, 2, 177 - 180.
  4. Fasidi, I.O and Adesomoju, A.A. (1981). Gall formation in Chlorophora excelsa (Welw.) Benth: Inhibitor and promoter contents of juvenile leaf, mature leaf and gall.  Beitrage zur Biologie der Pflanzen, 55, 409 - 416.
  5. Okogun, J.I.; Adesomoju, A.A.; Adesida, G.A.; Lindner, H.J. and Habermehl, G. (1982). Roseanolone: A new diterpene from Hypoestes rosea. Zeitschrifts fur Naturforschung, 37C, 558 – 561.
  6. Adesomoju, A.A. ­(1982). Constituent alkaloids of Rungia grandis T. (Acanthaceae).  International Journal Of Crude Drug Research, 20, 113 - 115.
  7. Adesomoju, A.A.; Rawal, V.H.; Laksmikantham, M.V. and Cava, M.P (1985)  Cimilophytine, a new bisindole alkaloid from Haplophyton cimicidum (Apocynaceae).  Journal of Organic Chemistry, 48, 3015 -3017.
  8. Adesomoju, A.A.; Okogun, J.I.; Cava, M.P. and Caroll, P.J. (1983). Roseadione, a diterpene ketone from Hypoestes rosea, Phytochemistry,  22, 2535 - 2536
  9. Adesomoju, A.A.; Lakshmikantham, M.V. and Cava, M.P. (1983).  Norisohaplophytine and haplocidiphytine - new bisindole alkaloids fromHaplophyton cimicidum (Apocynaceae).  Heterocycles,  20, 1511 - 1517.
  10. Adesomoju, A.A.; Okogun , J.I.; Cava, M.P. and Caroll, P.J. (1983). Hypoestoxide, a new diterpene from Hypoestes rosea (Acanthaceae)  Heterocycles, 20, 2125 - 2128 
  11. Adesomoju, A.A.; and Fasidi, I.O. (1984). Comparative study of some endogenous phytohormones in dormant and germinated seeds ofChlorophora excelsa (Welw) Benth.  Nigerian Journal of Science, 18, 6 - 8
  12. Adesomoju, A.A. and Okogun, J.I. (1984). Roseatoxide and dihypoestoxide: additional new diterpenoids from Hypoestes rosea. Journal of Natural Products, 47, 308 - 311.
  13. Adesomoju, A.A.; Davis, W.A.; Rajaraman, R; Pelletier, J.C. and Cava, M.P. (1984). Total synthesis of leucoxylonine. Journal of Organic Chemistry,  46, 3220 - 3222.
  14. Odunfa, S.A. and Adesomoju, A.A. (1985). Effects of fermentation on the free fatty acids of African locust bean during Iru production. Journal of Plant Foods, 6, 111- 115
  15. Adesomoju, A.A. and Okogun, J.I. (1985).  Phytochemical investigation of Phaylopis falcisepala.  Fitoterapia, 56, 279 - 280
  16. Okogun, J.I. and Adesomoju, A.A. (1985). Isolation of polycarpol fromAnnonidium manni.  Fitoterapia, 56, 252 -253
  17. Odunfa, S.A. and Adesomoju, A.A. (1986). Fatty acid composition of African locust bean (Parkia biglobosa). Chemie Mikrobiologie Technologie der Lebensmite, 10, 125 - 127
  18. Adesomoju, A.A. and Adesogan, E.K. (1987).  Chemical examination ofIcacina trichantha.  Bulletin of the Chemical Society of Nigeria, 12, 69 - 71.
  19. Adesomoju, A.A. (1987) Fatty acid composition of the seed oil ofChlophora excelsa.  Bulletin of the Chemical Society of Nigeria, 12, 69 -71.
  20. Rajeswari, S.; Adesomoju, A.A. and Cava, M.P. (1989).  Synthesis of new gramine-type analogs of CC - 1065.  Journal of Heterocyclic Chemistry, 26, 557 - 567
  21. Ekundayo, O.; Bakare, O.; Adesomoju, A.A. and Stahl-Biskup, E. (1990).  Nigerian sweet orange leaf oil composition.  Journal of Essential Oil Research, 2, 199 - 201
  22. Adesomoju, A.A. (1990).  Scopoletin from root of Rytiginia nigerica. Nigerian Journal of Science, 24, 25 - 26.
  23. Ekundayo, O.; Bakare, O.; Adesomoju, A.A. and Stahl-Biskup, E. (1990). Leaf volatile oil composition of mandarin [Citrus resticulata) from Nigeria. Journal of Essential Oil Research, 2, 329-330.
  24. Ekundayo, O.: Bakare, O.; Adesomoju, A.A. and Stahl-Biskup, E. (1990). The composition of lemon petitgrain oil (Citrus limon (L) Burn).  Journal of Essential Oil Research, 2, 269-270.
  25. Adesomoju, A.A.; Ekundayo, O.; Oke, T.; Eramo, T.; Laakso, I and Hiltunen, E. (1991). Volatile constituents of Monodora tenuifolia fruit oil.  Planta Medica, 57, 393-394.
  26. Ekundayo, O.; Bakare, O; Adesomoju, A.A.; Stahl-Biskup, E. (1991). Composition of the leaf oil of grapefruit (Citrus paradisi Macf). Journal of Essential Oil research, 3, 55-56.
  27. Ekunadayo, O.; Bakare, O; Adesomoju, A.A.; Stahl-Biskup, E. (1991). Volatile constituents of the leaf oil of Nigerian lime (Citrus aurantifolia).Journal of Essential Oil Research, 3, 119-120.
  28. Adesomoju, A.A.; Lakshmikantham, M.V. and Cava, M.P. (1991) Cimiciduphytine - A new dimeric indole alkaloid from Haplophyton cimicidum (Apocynacese). Heterocycles, 32, 1461 - 1462.
  29. Adesomoju, A.A. (1993). Naphthaquinones and triterpenoids of the fruits of Diospyros monbuttensis. Nigerian Journal of Science, 27, 215-218.
  30. Adesomoju, A.A. (1999). Chemical investigation of Laggera alata. Nigerian Journal of Science, 33, 171-175.
  31. Ekpendu, T.O.E; Adesomoju, A.A.; Ekundayo, O. and Okogun, J.I. (1993) Constituents of the volatile oil of Mitracarpus scaber Zucc. Flavour and Fragrance Journal, 8, 269-271.
  32. Ekpendu, T.O.; Akah, P.A.; Adesomoju, A.A. and Okogun, J.I. (1994). Antiinflamatory and antimicrobial activities of Mitracarpus scaberextracts International Journal of Pharmacognosy, 32, 191-196.
  33. Adesomoju, A.A.; Okogun, J.I.; Sadler, I.H.; Connolly, J.D. and Cava, M.P. (1996). 7-epi-cryptomeridiol, a new sesquiterpenoid from Laggera pterodonta. "Progress in Natural Product V" Royal Society of Chemistry at University of Notthingham 15-18 July 1996.
  34. Adesomoju, A.A.; Ajayi, S.O; Gbadegesin, A.S.; Adenikinju, A and Amubode, F.O. (1998). Delta State Environmental Action Plan. Technical Report commissioned by The Federal Environmental Protection Agency (FEPA) and The World Bank
  35. Adesomoju, A.A.; Ajayi, S.O.; Gbadegesin, A.S.; Adenikinju, A and Amubode,    F.O. (1998). Edo State Environmental Action Plan. Technical Report commissioned by The Federal Environmental Protection Agency (FEPA) and The World Bank.
  36. Ekpendu, T.O; Adesomoju, A.A. and Okogun, J.I. (1998). Chemical constituent of the extractives of Napoleonaea imperialis P. Beauv.  (Lecythidaceae). Journal of Pharmaceutical Research and Development, 3, 75-80.
  37. Ekpendu, T.O; Adesomoju, A.A; Okogun, J.I; Laakso, I (2000). The screening of Mitracarpus villosus (SW) DC. (Rubiaceae) volatile oil for biological activity. J. Chem. Soc. Nigeria, 25, 61-65.
  38. Ekpendu, T.O; Adesomoju, A.A and Okogun, J.I. (2001). Chemical Studies of Mitracarpus villosus (SW) DC. – a medicinal rubiaceae weed. J. Chem. Soc. Nigeria, 26, 69-74.
  39. Orisadipe, A; Amos, S; Adesomoju, A; Binda, L; Emeje, M; Okogun, J;  Wambebe  and Gamaniel, K. (2001). Spasmolytic activity of methyl angolensate: a triterpenoid isolated from   Entandrophragma angolense. Biol. Pharm. Bull ; 24(4), 364-367. Read abstract

  40. Ojo-Amaize, E.A; Kapahi, P; Kakkanaiah, V.N; Takahashi, T; Shalom-Barak, T; Cottam, H.B; Adesomoju, A.A; Nchekwube, E.J; Oyemade, O.A; Karin, M; and   Okogun, J.I. (2001). Hypoestoxide, a novel anti-inflammatory natural diterpene,  inhibits the activity of ikb kinase. Cellular Immunology 209,149-157.
  41. Ojo-Amaize, E.A; Nchekwebe, E.J; Cottam, H.B; Bai, R; Verdier-Pinard, P; Kakkanaiah, V.N; Varner, J.A; Leoni, L; Okogun, J.I; Adesomoju, A.A; Oyemade, O.A and Hamel, E. (2002). Hypoestoxide, a natural nonmutagenic diterpenoid with antiangiogenic and antitumor activity: possible mechanisms of action. Cancer Research 62, 4007-4014. Read abstract

  42. Amos, S; Orisadipe, A; Binda, L; Enieje, M; Adesomoju, A; Okogun, J; Akah, P; Wambebe, C and Gamaliel, K. (2002). Behavioural effect in rodents of methyl angolensate, a triterpenoid isolated from E. angolensate. Pharmacology and Toxicology 91, 71-76.
  43. Orisadipe, A.T; Adesomoju, A.A; D’Ambrosio, M; Guerriero, A. and Okogun, J.I. (2005) Tricullane triterpenes from the leaf extract ofEntandrophragma angolensate. Phytochemistry 66 (19), 2324-2328.
  44. Ojo-Amazie, E. A; Nchekwube, E.J; Cottam, H.B; Oyemade, O.A;Adesomoju, A.A and Okogun, J.I. (2007). Plasmodium berghei: antiparasiditic effects of orally administered hypoestoxide in mice. Experimental Parasitology 117 (2), 218-221. Read abstract

  45. Adebayo A. Lasisi and Akinbo A. Adesomoju (2012). New monoacylglycerol and antimicrobial constituents from stem bark ofBerlinia confusa. Journal of Herbs, Spices and Medicinal Plants, 18, 1-24.Read abstract

  46. Nneka N. Ibekwe; Abayomi T. Orishadipe; Helena Boshoff; Akinbo A. Adesomoju; Joseph I. Okogun and Clifton E. Barry (2012). In vitroantimycobacterial studies on the leaf extracts and fractions of Pavetta crassipes K. Schum, 6 (2), 55 – 58. Read abstract